Agreed - it's on our roadmap to a) work well with async loaders (including supporting HTML5's async attribute) and b) adding dependency management capabilities.
6 votesHoward Dierking commented
Our current design thinking is to add 'optimization mode' control for transforms (e.g. "apply this minification transform when optimizations are enabled|disabled|both"). This would be a part of adding the transform. Does this approach sound like it would work for you?